Navigating IVIG Complexity: How the Right Integrated Partner Can Help Streamline Infusion Management

Navigating IVIG Complexity: How the Right Integrated Partner Can Help Streamline Infusion Management

The Growing Complexity of IVIG Management

Intravenous immunoglobulin (IVIG) therapy has become increasingly central to specialty practices treating immunodeficiency, autoimmune, and neurological conditions. While these therapies offer transformative benefits for patients, they present significant operational challenges that can overwhelm even well-resourced practices.

The complexity stems from multiple factors: infusion durations ranging from 2 to 6 hours, individualized pre-medication protocols, stringent monitoring requirements, and the critical need to manage potential infusion reactions, all while maintaining efficient chair utilization and practice profitability.

Understanding the Operational Burden

According to a comprehensive cross-institutional protocol review, "Administering IVIG requires careful attention to dosing, infusion rates, pre-medications, and reaction management, as variability in these factors can significantly impact patient safety" (Payne et al., 2025). Maximum infusion rates vary widely across institutions from 2.4 to 8 mL/kg/hr, highlighting the lack of standardization that complicates scheduling and staffing.

The administrative burden extends far beyond the infusion itself. A 2023 quality improvement study found that "it can still be difficult for patients to receive timely access to therapies given the administrative burden, including the need to complete a manual review process" for prior authorizations (Seifert et al., 2023). Practices must navigate complex insurance requirements, manage inventory for high-cost medications, and maintain compliance with evolving regulations. Ensuring optimal patient care becomes challenging in the face of these circumstances.

The Hidden Costs of In-House Management

Managing infusion services involves far more than supervising IV drips and monitoring patients. The operational reality is that "infusion nurses are involved in communications, education, medication administration, and documentation, and they are often rapidly shifting between tasks or multitasking" throughout their shifts (Zhao et al., 2025). This constant behind-the-scenes activity means that traditional metrics like chair utilization, which may show active treatment occurring only a fraction of the time, fail to capture the true resource intensity of infusion programs.  

Practices often discover too late that the staffing, training, and administrative requirements far exceed initial projections.

Infusion reactions, occurring in approximately 5% of IVIG infusions (Palabrica et al., 2013), can double scheduled chair time and create cascading delays throughout the day. Managing these disruptions requires experienced staff who can quickly assess, intervene, and adjust schedules. This expertise takes years to develop.

Patient Outcomes Depend on Operational Excellence

Research demonstrates that office-based infusion settings achieve superior adherence rates compared to hospital or home settings. A study found that 79.3% of office-based patients remained on treatment by day 200, compared to only 64.4% for home-based infusions (Giese-Kim et al., 2020). However, achieving these outcomes requires operational efficiency that many practices struggle to maintain independently.

The Case for Strategic Partnerships

Given these complexities, many specialty practices are discovering that partnering with infusion management experts provides the optimal solution. Rather than attempting to build and maintain infusion capabilities in-house, strategic outsourcing allows practices to:

  • Eliminate administrative burden while maintaining patient relationships
  • Avoid capital investments in infrastructure and training
  • Ensure consistent, high-quality care through specialized expertise
  • Focus clinical resources on diagnosis and treatment planning
  • Maximize revenue without operational headaches

OnePulse Connect - Infusion from Elevate Health Technologies: Your Complete Solution

OnePulse Connect - Infusion provides a complete turnkey solution that manages all aspects of IVIG and specialty infusion programs from inception through ongoing operations. Our comprehensive approach includes:

  • Complete administrative management: From benefits verification to prior authorizations, we handle the entire administrative burden
  • Expert clinical support: Our specialized infusion nurses bring years of experience in managing complex therapies
  • Technology integration: Seamless EHR connectivity ensures real-time visibility and coordination
  • Regulatory compliance: We maintain all necessary certifications and handle DSCSA requirements
  • Patient engagement: Robust digital communications, assessments and monitoring tools maintain the high adherence rates critical for success

By partnering with OnePulse Connect - Infusion, practices can offer state-of-the-art infusion services without operational complexity, allowing them to focus on what they do best, caring for patients.

Conclusion

The management of IVIG and complex infusion therapies represents both an opportunity and a challenge for specialty practices. While these services are essential for patient care and can enhance practice revenue, the operational complexity often exceeds what practices can efficiently manage independently.

Partnering with OnePulse Connect - Infusion provides the expertise, infrastructure, and support necessary to deliver exceptional infusion services while eliminating operational burden. In today's healthcare environment, this strategic approach represents not just an option, but an essential strategy for practices committed to providing comprehensive, high-quality care.

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Learn More about your turnkey In-Office Infusion program here.

About Elevate Health Technologies:

Elevate Health Technologies is committed to making healthcare better for everyone. We collaborate with healthcare providers, patients, pharmaceutical manufacturers, and payors to deliver innovative technologies that truly make a difference. OnePulse Connect empowers healthcare practices by optimizing efficiency and streamlining care, whether through buy-and-bill management, inventory tracking, medically integrated dispensing, or in-office infusion services. Our tailored approach delivers deep data insights, advanced analytics, and dynamic patient engagement platforms. Together, we move as One Pulse, driving smarter, faster, and more connected health technologies for improved outcomes and better patient experiences.

Visit www.elevateht.com to learn more.

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References

  • Giese-Kim N, Wu M, Dehghan M, Sceats LA, Park KT. Home Infliximab Infusions Are Associated With Suboptimal Outcomes Without Cost Savings in Inflammatory Bowel Diseases. Am J Gastroenterol. 2020 Oct;115(10):1698-1706.
  • Palabrica FR, Kwong SL, Padua FR. Adverse events of intravenous immunoglobulin infusions: a ten-year retrospective study. Asia Pac Allergy. 2013;3(4):249-256.
  • Payne ML, Smetana KS, May CC. IVIG Administration: Lessons from Cross-Institutional Protocol Review. Hosp Pharm. 2025 May 17:00185787251340651. PMCID: PMC12085551.
  • Seifert CL, et al. Navigating Access and Optimizing Medication Infusions in an Academic Medical Center: A Quality Improvement Study. Healthcare. 2023;11(4):111. PMCID: PMC10366736.
  • Zhao J, Sherman B, McCracken A, Watkins S, Rusinko K. Development of Productivity Standards for Ambulatory Infusion Suite Nurses Within a Multi-Entity Health System. National Home Infusion Association. 2025.